Laboratory of Biophysics and p53 protein biology
Karolinska Institute is the largest medical university in Sweden and is ranked among the top medical universities in the world. We are part of the Department of Oncology-Pathology.
Medical University of Warsaw is the largest and the oldest, most prestigious medical school in Poland. We are part of the Faculty of Medicine, Department of Biochemistry.
June, 2024
We are happy to work with a new student, Anna Chudoba, from the Biomedicine programme KI, who stays with us for the Karolinska Institute Summer School Project.
March, 2024
Happy to share our newest review on p53 biology and reactivation in AML.
April, 2023
Happy to contribute to this important work on Apoptotic cell death in disease—Current understanding of the NCCD 2023 - 'a fundamental CONSENSUS PAPER defining cell death mechanisms in disease'.
June, 2022
Our new review article about mutTP53 and mutEGFR NSCLC in IJMS MDPI.
June, 2022
A novel allosteric mechanism of p53 reactivation for improved cancer therapy.
Unlike others, we target the N-terminal region of p53 pharmacologically to trigger the allosteric shift in p53 and prevent it from interactions with MDM2 and MDM4.
June, 2021
Research on drug repurposing for the improved therapy in TP53-mutated AML awarded.
August, 2021
We discovered previously overlooked correlations between specific amino acid deviations in p53 and the lifespans across species in Animal Kingdom. Species with extended lifespans have certain characteristic amino acid substitutions in the p53 DNA-binding domain that alter p53 function. Welcome to read more here
December, 2021
We are starting a new Lab at the Medical University of Warsaw (MUW/WUM).
More news
November, 2023
September, 2022
May, 2022
July, 2022